Arthritis Res Ther 2018 Mar 22;20(1):52. Epub 2018 Mar 22.
Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany.
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Front Immunol 2018 22;9:428. Epub 2018 Mar 22.
Department of Rheumatology, University of Lübeck, Lübeck, Germany.
Systemic sclerosis (SSc) is a severe chronic autoimmune disease with high morbidity and mortality. Sera of patients with SSc contain a large variety of autoantibody (aab) reactivities. Among these are functionally active aab that bind to G protein-coupled receptors (GPCR) such as C-X-C motif chemokine receptor 3 (CXCR3) and 4 (CXCR4). Read More
Arthritis Res Ther 2011 13;13(5):R166. Epub 2011 Oct 13.
Immunology and Allergy, University Hospital and School of Medicine, 4 rue Gabrielle Perret Gentil, Geneva 1211, Switzerland.
Introduction: T cell abnormalities have been associated with the pathogenesis of systemic sclerosis (SSc). Recently, besides T helper (Th)17 cells, the Th22 subset has been identified in humans. Our purpose was to investigate the pattern of cytokines produced and chemokine-receptors expressed by peripheral blood (PB) Th cells in SSc and healthy donors (HD) focusing on cells producing interleukin (IL)-17 and IL-22 and to identify specific clinical associations. Read More
Arthritis Res Ther 2014 Jan 28;16(1):R29. Epub 2014 Jan 28.
Introduction: Vasculopathy, inflammatory fibrosis and functional autoantibodies (Abs) are major manifestations of systemic sclerosis (SSc). Abs directed against the angiotensin II type 1 receptor (AT₁R) and endothelin-1 type A receptor (ETAR) are associated with characteristic disease features including vascular, inflammatory, and fibrotic complications indicating their role in SSc pathogenesis. Therefore, the impact of anti-AT₁R and anti-ETAR Abs on initiation of inflammation and fibrosis was analyzed. Read More
Arthritis Res Ther 2014 Mar 11;16(2):R65. Epub 2014 Mar 11.
Introduction: Agonistic autoantibodies (Aabs) against the angiotensin II receptor type 1 (AT1R) and the endothelin receptor type A (ETAR) have been identified in patients with systemic sclerosis (SSc). In our present study, we examined the expression of the AT1R and the ETAR in human immune cells and the pathological effects mediated through these receptors by their corresponding Aabs.
Methods: Protein expression of AT1R and ETAR on peripheral blood mononuclear cells (PBMCs) from healthy individuals and SSc patients was analyzed using flow cytometry, and mRNA expression of both receptors in PBMCs from healthy donors was examined by real-time PCR. Read More