GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion.

Authors:
Antonietta Franco
Antonietta Franco
Washington University School of Medicine
Italy
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Roberto Pacelli
Roberto Pacelli
Institute of Biostructures and Bioimaging
Italy
Nella Prevete
Nella Prevete
University of Naples Federico II
Claudio Procaccini
Claudio Procaccini
Laboratorio di Immunologia
Italy
Giuseppe Matarese
Giuseppe Matarese
Università di Salerno
Fisciano | Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy

Cell Death Discov 2018 Dec 14;4:25. Epub 2018 Feb 14.

3Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Italy.

The modern understanding of the G protein-coupled receptor kinase 2 has grown towards the definition of a stress protein, for its ability to rapidly compartmentalize within the cell in response to acute stimulation. Also, mitochondria can be regulated by GRK2 localization. We show that Ionizing Radiation (IR) exposure acutely damages mitochondria regarding mass, morphology, and respiration, with recovery in a framework of hours. This phenomenon is actively regulated by GRK2, whose overexpression results to be protective, and reciprocally, deletion accelerates degenerative processes. The regulatory effects of the kinase involve a new interactome that includes binding HSP90 and binding and phosphorylation of the key molecules involved in the process of mitochondrial fusion and recovery: MFN-1 and 2.

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http://dx.doi.org/10.1038/s41420-018-0028-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841414PMC
December 2018
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2 Citations

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