Psychother Psychosom 2018 1;87(2):118-120. Epub 2018 Mar 1.
Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Environ Sci Process Impacts 2021 Sep 20. Epub 2021 Sep 20.
School of Public Health, University of Nevada Reno, 1664 N. Virginia Street, 89557-274, Reno, Nevada, USA.
One of the ultimate goals of environmental exposure science is to mechanistically understand how chemical properties and human behavior interactively determine human exposure to the wide spectrum of chemicals present in the environment. This comprehensive review assembles state-of-the-art knowledge of the role of partitioning, dissociation, mass transfer, and reactive properties in human contact with and absorption of organic chemicals oral, dermal, and respiratory routes. Existing studies have revealed that chemicals with different properties vary greatly in mass distribution and occurrence among multiple exposure media, resulting in distinct patterns of human intake from the environment. Read More
Hepatol Commun 2021 Jul 1. Epub 2021 Jul 1.
Laboratory of Molecular Immunology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically. Here, we sought means to neutralize the ability of extracellular DNA to induce deleterious tissue inflammation when drug-induced liver injury had already ensued. Read More
Elife 2021 Sep 7;10. Epub 2021 Sep 7.
Harvard University, Cambridge, United States.
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer protection against diverse influenza strains have been isolated. Structural and biochemical characterization of these bnAbs has provided molecular insight into how they bind distinct antigens. However, our understanding of the evolutionary pathways leading to bnAbs, and thus how best to elicit them, remains limited. Read More
Antimicrob Agents Chemother 2021 Aug 30:AAC0118421. Epub 2021 Aug 30.
Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA.
has emerged as a successful pathogen owing to its intrinsic drug resistance. Macrolide and lincosamide antibiotics share overlapping binding sites within the ribosome and common resistance pathways. Nevertheless, while is initially susceptible to macrolides, they are completely resistant to the lincosamide antibiotics. Read More
MethodsX 2021 30;8:101206. Epub 2020 Dec 30.
Department of Biological and Environmental Sciences, University of Gothenburg, Medicinaregatan 18 A, Box 463, 413 90 Göteborg, Sweden.
There is increasing concern that particulate contaminants including manufactured nanomaterials and nano- and microplastics taken up and or accumulating in lower-trophic level aquatic organisms results in dietary exposure of fish feeding on these organisms. Controlled feeding studies can help advance our understanding of dietary uptake, bioaccumulation, and associated effects of (nano)particulate contaminants in fish, and also provide information about their likelihood to be transferred along the trophic chain and or to act as vector for other, surface-adsorbed pollutants. However, traditional approaches to prepare test feed for dietary exposure studies where commercial fish feed such as flakes, granules or pellets are soaked or spray-spiked with dissolved chemicals are not well suitable for (nano-)particulate contaminants. Read More