J Virol 2018 05 27;92(10). Epub 2018 Apr 27.
Emory Vaccine Center, Emory University, Atlanta, Georgia, USA
Neuroimage 2021 Feb 27:117919. Epub 2021 Feb 27.
Graduate Program in Neuroscience, University of Western Ontario, London, Canada; Robarts Research Institute, University of Western Ontario, London, Canada; The Brain and Mind Institute, University of Western Ontario, London, Canada; Department of Physiology and Pharmacology, University of Western Ontario, London, Canada. Electronic address:
Unilateral damage to the frontoparietal network typically impairs saccade target selection within the contralesional visual hemifield. Severity of deficits and the degree of recovery have been associated with widespread network dysfunction, yet it is not clear how these behavioural and functional changes relate with the underlying structural white matter tracts. Here, we investigated whether recovery after unilateral prefrontal cortex (PFC) lesions was associated with changes in white matter microstructure across large-scale frontoparietal cortical and thalamocortical networks. Read More
Nat Commun 2021 Mar 1;12(1):1346. Epub 2021 Mar 1.
Clover Biopharmaceuticals, Chengdu, China.
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Read More
Stem Cell Res Ther 2021 Mar 1;12(1):156. Epub 2021 Mar 1.
Kunming Key Laboratory of Stem Cell and Regenerative Medicine, 920th Hospital of the PLA Joint Logistics Support Force, Kunming, 650032, Yunnan Province, China.
Background: Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it is particularly important to find new anti-aging treatments. Read More
Psychoneuroendocrinology 2021 Feb 11;127:105154. Epub 2021 Feb 11.
School of Psychology, Trinity College Dublin, Dublin, Ireland; Department of Psychiatry at the School of Medicine, Trinity College Dublin, Dublin, Ireland; Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
In females, pubertal onset appears to signal the opening of a window of increased vulnerability to the effects of stress on neurobehavioral development. What is the impact of pubertal timing on this process? We assessed the effects of pubertal timing and stress on behavior and amygdala functional connectivity (FC) in adolescent female macaques, whose social hierarchy provides an ethologically valid model of chronic psychosocial stress. Monkeys experienced puberty spontaneously (n = 34) or pubertal delay via Lupron treatment from age 16-33 months (n = 36). Read More
Chem Res Toxicol 2021 Mar 1. Epub 2021 Mar 1.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation in the liver and associates with obesity, hyperlipidemia, and insulin resistance. NAFLD could lead to nonalcoholic steatohepatitis (NASH), hepatic fibrosis, cirrhosis, and even cancers. The development of therapy for NAFLD has been proven difficult. Read More