Clin Exp Rheumatol 2018 May-Jun;36 Suppl 112(3):47-50. Epub 2018 Feb 21.
Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital; and Faculty of Medicine and Life Sciences, University of Tampere, Finland.
Arthritis Res Ther 2009 15;11(5):R156. Epub 2009 Oct 15.
Rhumatologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U802, Université Paris-Sud 11, 78 rue du Général Leclerc, 94270, Le Kremlin Bicêtre, France.
Introduction: Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as a possible biomarker in primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
Methods: We measured plasma levels of total, platelet and leukocyte MPs by prothrombinase capture assay and flow cytometry in 43 patients with pSS, 20 with SLE and 24 with RA and in 44 healthy controls (HCs). Read More
Clin Rheumatol 2015 May 8;34(5):879-85. Epub 2015 Jan 8.
Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, 158 Shangtang Road, 310014, Hangzhou, China.
Previous studies suggested a pathological role for the death decoy receptor 3 (DcR3) in systemic lupus erythematosus (SLE) and rheumatic arthritis (RA). Herein, the expression of DcR3 in primary Sjögren's syndrome (pSS) and the relationship with clinical characteristics were investigated. The serum DcR3 levels of pSS patients and healthy controls were measured by ELISA. Read More
Clin Exp Rheumatol 2011 Nov-Dec;29(6):970-6. Epub 2011 Dec 22.
Department of Internal Medicine, National University Bundang Hospital, Seoul, Republic of Korea.
Objectives: To compare salivary cytokine profiles in patients with primary Sjögren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to investigate whether cytokine levels are correlated with clinical parameters of pSS patients.
Methods: Un-stimulated whole saliva samples were obtained from pSS patients (n=30) classified according to the criteria of the American European Consensus Group. Age- and gender-matched non-SS sicca patients (n=30) and non-sicca subjects (n=25) served as controls. Read More
Blood 2006 Aug 20;108(3):983-5. Epub 2006 Apr 20.
MIIB-NIAMS-NIH, Bldg 10, Rm 9N262, 10 Center Dr, Bethesda, MD 20892, USA.
Interleukin 12 (IL-12) is a major inducer of interferon gamma (IFN-gamma) and the principal mediator of T helper 1 (Th1) differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC), furin, was one of the most consistently IL-12-induced genes in T cells, and among PCs was the only one regulated by this cytokine. Read More