Clin Exp Rheumatol 2018 May-Jun;36 Suppl 112(3):41-46. Epub 2018 Jan 31.
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, USA.
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Ann Rheum Dis 2016 Mar 5;75(3):617-22. Epub 2015 Feb 5.
Division of Nephrology, University of Virginia, Charlottesville, Virginia, USA Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.
Objectives: Autoantibodies reactive with Ro52 are often found in sera of patients with Sjögren's syndrome (SS). This study was undertaken to investigate the role of Ro52-induced immune responses in pathogenesis of SS.
Methods: New Zealand Mixed (NZM) 2758 mice were immunised with Ro52 in alum adjuvant. Read More
Clin Exp Immunol 2014 Jul;177(1):244-52
Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway.
Ro52 is an E3 ubiquitin ligase with a prominent regulatory role in inflammation. The protein is a common target of circulating autoantibodies in rheumatic autoimmune diseases, particularly Sjögren's syndrome (SS). In this study we aimed to investigate the expression of the SS target autoantigen Ro52 in salivary glands of patients with primary Sjögren's syndrome (pSS). Read More
Mol Immunol 2006 Feb;43(6):588-98
Rheumatology Unit, Department of Medicine, CMM L8:04, Karolinska Institutet, SE-171 76 Stockholm, Sweden.
Ro52, one of the major autoantigens in the rheumatic disease Sjögren's syndrome (SS), belongs to the tripartite motif (TRIM) or RING-B-box-coiled-coil (RBCC) protein family, thus comprising an N-terminal RING, followed by a B-box and a coiled-coil region. Several different proteomic functions have been suggested for Ro52, including DNA binding, protein interactions and Zn(2+)-binding. To analyze the presence and/or absence of these functions and, in particular, map those to different subregions, the modular composition of the Ro52 protein was experimentally characterized. Read More
Immunology 2002 Jun;106(2):246-56
Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge UK.
The 52 000 MW Ro/SS-A (Ro52) protein is a major target of autoantibodies in autoimmune conditions such as systemic lupus erythematosus and Sjögren's syndrome. Recent genomic and bioinformatic studies have shown that Ro52 belongs to a large family of related RING/Bbox/coiled-coil (RBCC) tripartite motif proteins sharing overall domain structure and 40-50% identity at the amino acid level. Ro52 also has a B30. Read More