Clin Exp Rheumatol 2018 May-Jun;36(3):508-512. Epub 2018 Jan 31.
Division of Paediatric Rheumatology, The Affiliated Children's Hospital, Capital Institute of Paediatrics, Beijing, China.
Gene 2018 Jun 8;658:105-112. Epub 2018 Mar 8.
Departments of Clinical Pharmacology and Therapeutics, Nizam's Institute of Medical Sciences (NIMS), Telangana, Hyderabad, India. Electronic address:
Objective: Endothelial nitric oxide synthase (eNOS) is constitutively expressed by vascular endothelium including glomerular endothelium. Functional polymorphisms, -786T>C (rs2070744) promoter variant, 27 bp VNTR (4b/a) in intron 4 and 894G>T (rs1799983) exon variant of eNOS are known to alter the eNOS expression and activity leading to altered NO levels and contribute to the development of vascular and renal disease risk. Thus it might have a role in SLE risk and development of glomerulonephritis. Read More
Lupus 2011 Jun 8;20(7):700-8. Epub 2011 Apr 8.
Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait.
Endothelial nitric oxide synthase (eNOS) catalyses the production of nitric oxide, which has been shown to participate in the pathogenesis of systemic lupus erythematosus (SLE). eNOS gene polymorphism may have an effect on eNOS gene expression, eNOS protein synthesis and enzymatic activity. We investigated the influence of eNOS gene polymorphisms on susceptibility to SLE. Read More
J Rheumatol 2004 Sep;31(9):1756-62
Medical Research Service, Ralph H. Johnson Veterans Administration Medical Center and Medical University of South Carolina, Charleston, South Carolina, USA.
Objective: Genetic polymorphisms in the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) are linked with expression and/or progression of renal disease. We hypothesized that polymorphisms in the genes coding for ACE and eNOS may influence the development and/or progression of systemic lupus erythematosus (SLE) and lupus nephritis given their linkage with other renal diseases.
Methods: DNA from patients with SLE (n = 227) and their age and sex matched controls (n = 275) from the Carolina Lupus (CLU) Study cohort was assessed for ACE and eNOS polymorphisms. Read More
J Rheumatol 2004 Nov;31(11):2163-8
School of Medicine, Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Colombia.
Objective: In systemic lupus erythematosus (SLE), endothelial nitric oxide synthase (eNOS) gene locus has been found to be suggestive of linkage with disease, nitric oxide (NO) is produced in significant amounts, and endothelial cell dysfunction is observed. eNOS gene polymorphism may affect both the synthesis of eNOS protein and its enzymatic activity. We examined the influence of eNOS gene polymorphisms on susceptibility to SLE. Read More