Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.

Authors:
Shuo Chen
Shuo Chen
Dalian University of Technology
China
Adam Z Weitemier
Adam Z Weitemier
Oregon Health and Science University
United States
Xiao Zeng
Xiao Zeng
University of Nebraska-Lincoln
United States
Linmeng He
Linmeng He
Laboratory for Circuit and Behavioral Physiology
Xiyu Wang
Xiyu Wang
College of Medicine and Public Health
United States
Yanqiu Tao
Yanqiu Tao
Laboratory for Circuit and Behavioral Physiology
Yuki Hashimotodani
Yuki Hashimotodani
Graduate School of Medicine
Japan

Science 2018 02;359(6376):679-684

Laboratory for Circuit and Behavioral Physiology, RIKEN Brain Science Institute, Wakoshi, Saitama 351-0198, Japan.

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.

Abstract Video

Deep brain stimulation realized with the help of nanoparticles


Source: Research Square

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http://dx.doi.org/10.1126/science.aaq1144DOI Listing

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February 2018
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