Tratt. and L.: a study of anti-proliferative activity towards human cancer cells and antioxidant properties.

Nat Prod Res 2019 Jun 12;33(12):1809-1812. Epub 2018 Feb 12.

c Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry , Johannes Gutenberg University , Mainz , Germany.

In this study, we investigated for the first time the anti-proliferative and antioxidant properties of and . The aerial parts were extracted by maceration with -hexane, dichloromethane, and methanol. MPLC, GC, and GC-MS were used for the phytochemical study. The anti-proliferative activity was tested against MCF-7, A549, LNCaP, ACHN, and C32 cancer human cells. The antioxidant activity was measured by employing β-carotene bleaching, ABTS, DPPH, and FRAP tests. The Relative Antioxidant Capacity Index (RACI) was applied from the perspective of statistics. dichloromethane extract showed a remarkable anti-proliferative with an IC of 6.08 μg/mL against LNCaP cells. Experimental data indicate that species have interesting anti-proliferative and antioxidant properties that deserve more investigations to develop novel antineoplastic drugs.

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http://dx.doi.org/10.1080/14786419.2018.1437432DOI Listing
June 2019
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