Cell Biol Int 2018 Jun 1;42(6):747-753. Epub 2018 Mar 1.
Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, São Paulo, Brazil.
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Pharmacol Res 2008 May 22;57(5):332-8. Epub 2008 Mar 22.
Departamento de Investigaciones Biomédicas, Centro de Química Farmacéutica, Calle 200, Esq. 21, Playa, Ciudad de La Habana, Cuba.
Atherosclerosis is linked to a number of oxidative events ranging from low-density lipoprotein (LDL) oxidation to the increased production of intracellular reactive oxygen species (ROS). We have recently demonstrated that liver mitochondria isolated from the atherosclerosis-prone hypercholesterolemic LDL receptor knockout (LDLr(-/-)) mice have lower content of NADP(H)-linked substrates than the controls and, as consequence, higher sensitivity to oxidative stress and mitochondrial membrane permeability transition (MPT). In the present work, we show that oral supplementation with the antioxidants Mangifera indica L. Read More
Drug Metabol Drug Interact 2005 ;21(1):19-29
Centro Nacional para el Control Estatal de la Calidad de los Medicamentos, Playa, Habana, Cuba.
Vimang is an aqueous extract of Mangifera indica used in Cuba to improve the quality of life in patients suffering from inflammatory diseases. In the present study we evaluated the effects of Vimang at preventing reactive oxygen species (ROS) formation and lipid peroxidation in intact isolated rat hepatocytes. Vimang at 20, 50 and 100 microg/ml inhibited hepatocyte ROS formation induced by glucose-glucose oxidase. Read More
Phytother Res 2003 Dec;17(10):1182-7
Laboratorio de Farmacología, Centro de Química Farmacéutica, Ciudad de la Habana (Havana City), Cuba.
The present study investigated the effects of orally administered Vimang (an aqueous extract of Mangifera indica) and mangiferin (the major polyphenol present in Vimang) on mouse antibody responses induced by inoculation with spores of microsporidian parasites. Inoculation induced specific antibody production with an exponential timecourse, peaking after about one month. Vimang significantly inhibited this antibody production from about three weeks post-inoculation, and most markedly by four weeks post-inoculation; by contrast, mangiferin had no significant effect. Read More
J Pharm Pharmacol 2006 Mar;58(3):385-92
Laboratory of Pharmacology, Department of Biomedical Research, Center of Pharmaceutical Chemistry, P. O. Box 16042, Havana, Cuba.
Vimang is the brand name of formulations containing an extract of Mangifera indica L., ethnopharmacologically used in Cuba for the treatment of some immunopathological disorders, including bronchial asthma, atopic dermatitis and other allergic diseases. However, the effects of Vimang on allergic response have not been reported until now. Read More