Exploration into Uric and Cardiovascular Disease: Uric Acid Right for heArt Health (URRAH) Project, A Study Protocol for a Retrospective Observational Study.

Authors:
Giovambattista Desideri
Giovambattista Desideri
University of L'Aquila
Italy
Agostino Virdis
Agostino Virdis
University of Pisa
Edoardo Casiglia
Edoardo Casiglia
University of Padova
Italy
Claudio Borghi
Claudio Borghi
University of Bologna
Italy

High Blood Press Cardiovasc Prev 2018 Jun 9;25(2):197-202. Epub 2018 Feb 9.

Department of Medical and Surgical Science, Alma Mater Studiorum University of Bologna, Bologna, Italy.

The relevance of cardiovascular role played by levels of serum uric acid is dramatically growing, especially as cardiovascular risk factor potentially able to exert either a direct deleterious impact or a synergic effect with other cardiovascular risk factors. At the present time, it still remains undefined the threshold level of serum uric acid able to contribute to the cardiovascular risk. Indeed, the available epidemiological case studies are not homogeneous, and some preliminary data suggest that the so-called "cardiovascular threshold limit" may substantially differ from that identified as a cut-off able to trigger the acute gout attack. In such scenario, there is the necessity to clarify and quantify this threshold value, to insert it in the stratification of risk algorithm scores and, in turn, to adopt proper prevention and correction strategies. The clarification of the relationship between circulating levels of uric acid and cardio-nephro-metabolic disorders in a broad sample representative of general population is critical to identify the threshold value of serum uric acid better discriminating the increased risk associated with uric acid. The Uric acid Right for heArt Health (URRAH) project has been designed to define, as primary objective, the level of uricemia above which the independent risk of cardiovascular disease may increase in a significantly manner in a general Italian population.

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http://dx.doi.org/10.1007/s40292-018-0250-7DOI Listing

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June 2018

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