Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.

Authors:
Youssef Ezzyat Paul A Wanda Deborah F Levy Allison Kadel Ada Aka Isaac Pedisich Michael R Sperling Ashwini D Sharan Bradley C Lega Alexis Burks Robert E Gross Cory S Inman Barbara C Jobst Mark A Gorenstein Kathryn A Davis Gregory A Worrell Michal T Kucewicz Joel M Stein Richard Gorniak Sandhitsu R Das Daniel S Rizzuto Michael J Kahana

Nat Commun 2018 02 6;9(1):365. Epub 2018 Feb 6.

Department of Psychology, University of Pennsylvania, 433 South University Avenue, Philadelphia, PA, 19104, USA.

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-02753-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802791PMC
February 2018

Publication Analysis

Top Keywords

temporal cortex
12
lateral temporal
8
memory
6
effects open-loop
4
open-loop stimulation
4
stimulation target
4
cortex reliable
4
medial temporal
4
hippocampus medial
4
target hippocampus
4
reliable target
4
memory encoding
4
inconsistent effects
4
previous efforts
4
periods poor
4
stimulation previous
4
enhancement systems
4
memory enhancement
4
efforts reported
4
target memory
4

Altmetric Statistics


Show full details
801 Total Shares
11 Facebook Pages
18 Blogs
1 Google+ Users
78 News Outlets
1 Research Highlights
584 Tweets
1 Video Uploads
696 Citations

Similar Publications

Distinct and Common Large-Scale Networks of the Hippocampal Long Axis in Older Age: Links to Episodic Memory and Dopamine D2 Receptor Availability.

Authors:
Kristin Nordin Lars Nyberg Micael Andersson Nina Karalija Katrine Riklund Lars Bäckman Alireza Salami

Cereb Cortex 2021 Mar 2. Epub 2021 Mar 2.

Umeå Center for Functional Brain Imaging, Umeå University, S-90187 Umeå, Sweden.

The hippocampal longitudinal axis has been linked to dissociated functional networks relevant to episodic memory. However, the organization of axis-dependent networks and their relation to episodic memory in aging remains less explored. Moreover, age-related deterioration of the dopamine (DA) system, affecting memory and functional network properties, might constitute a source of reduced specificity of hippocampal networks in aging. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Structural reorganization of the cerebral cortex after vestibulo-cerebellar stroke.

Authors:
Julian Conrad Maximilian Habs Maxine Ruehl Rainer Boegle Matthias Ertl Valerie Kirsch Ozan Eren Sandra Becker-Bense Thomas Stephan Frank Wollenweber Marco Duering Marianne Dieterich Peter Zu Eulenburg

Neuroimage Clin 2021 Feb 23;30:102603. Epub 2021 Feb 23.

German Center for Vertigo and Balance Disorders (DSGZ), University Hospital, LMU Munich, Germany; Institute for Neuroradiology, University Hospital, LMU Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Objective: Structural reorganization following cerebellar infarcts is not yet known. This study aimed to demonstrate structural volumetric changes over time in the cortical vestibular and multisensory areas (i.e. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Medial Prefrontal High-Definition Transcranial Direct Current Stimulation to Improve Pain Modulation in Chronic Low Back Pain: A Pilot Randomized Double-blinded Placebo-Controlled Crossover Trial.

Authors:
Megan E McPhee Thomas Graven-Nielsen

J Pain 2021 Mar 3. Epub 2021 Mar 3.

Center for Neuroplasticity and Pain (CNAP), Aalborg University, Denmark. Electronic address:

Chronic low back pain (CLBP) is highly disabling, but often without identifiable source. Focus has been on impaired anti-nociceptive mechanisms contributing to pain maintenance, though methods of targeting this impairment remain limited. This randomised-controlled cross-over pilot trial used active versus sham medial prefrontal cortex (mPFC) high-definition transcranial direct current stimulation (HD-tDCS) for three-consecutive days to improve descending pain inhibitory function. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Task switching and the role of motor reprogramming in parietal structures.

Authors:
Vanessa A Petruo Christian Beste

Neuroscience 2021 Mar 3. Epub 2021 Mar 3.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Electronic address:

Human behaviour amazes with extraordinary flexibility and the underlying neural mechanisms have often been studied using task switching. Despite extensive research, the relative importance of "cognitive" and "motor" aspects during switching is unclear. In the current study we examine this question combining EEG analysis techniques and source localization to examine whether the selection of the response, or processes during the execution of the response, contribute most to switching effects. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Hippocampal-entorhinal system represents nested hierarchical relations between words during concept learning.

Authors:
Simone Viganò Manuela Piazza

Hippocampus 2021 Mar 6. Epub 2021 Mar 6.

CIMeC - Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy.

A fundamental skill of an intelligent mind is that of being able to rapidly discover the structural organization underlying the relations across the objects or the events in the world. Humans, thanks to language, master this skill. For example, a child learning that dolphins and cats can also be referred to as mammals, not only will infer the presence of a hierarchical organization for which dolphins and cats are subordinate exemplars of the category mammals, but will also derive that dolphins are, at least at one conceptual level, more similar to cats than to sharks, despite their indisputable higher perceptual similarity to the latter. Read More

View Article and Full-Text PDF
March 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap