Ann Thorac Med 2018 Jan-Mar;13(1):7-13
Department of Pediatrics, University of Chieti, 66100 Chieti, Italy.
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Pediatr Pulmonol 2016 Mar 4;51(3):225-42. Epub 2015 Dec 4.
Queensland Children's Medical Research Institute, Children's Health Queensland, Brisbane, Queensland, Australia.
Cough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bronchitis (PBB), especially in children aged <6 years. Read More
Pediatr Ann 2015 Aug;44(8):329-36
Pro: Children with chronic cough present a diagnostic challenge. Protracted bacterial bronchitis (PBB) is a chronic, persistent bacterial infection of conducting airways defined by the presence of cough for longer than 4 weeks that resolves with antimicrobial therapy and without an alternative diagnosis. The diagnosis is made by the findings of increased bronchial secretions and edema of the lower airways on flexible bronchoscopy and positive cultures on bronchoalveolar lavage. Read More
Pediatr Pulmonol 2008 Jun;43(6):519-31
Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia.
The role of persistent and recurrent bacterial infection of the conducting airways (endobronchial infection) in the causation of chronic respiratory symptoms, particularly chronic wet cough, has received very little attention over recent decades other than in the context of cystic fibrosis (CF). This is probably related (at least in part) to the (a) reduction in non-CF bronchiectasis in affluent countries and, (b) intense focus on asthma. In addition failure to characterize endobronchial infections has led to under-recognition and lack of research. Read More
Trials 2013 Sep 5;14:282. Epub 2013 Sep 5.
Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Brisbane, QLD, Australia.
Background: Recurrent protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are characterised by a chronic wet cough and are important causes of childhood respiratory morbidity globally. Haemophilus influenzae and Streptococcus pneumoniae are the most commonly associated pathogens. As respiratory exacerbations impair quality of life and may be associated with disease progression, we will determine if the novel 10-valent pneumococcal-Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) reduces exacerbations in these children. Read More