Lingual Gyrus Surface Area Is Associated with Anxiety-Depression Severity in Young Adults: A Genetic Clustering Approach.

eNeuro 2018 Jan-Feb;5(1). Epub 2018 Jan 19.

Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia.

Here we aimed to identify cortical endophenotypes for anxiety-depression. Our data-driven approach used vertex-wise genetic correlations (estimated from a twin sample: 157 monozygotic and 194 dizygotic twin pairs) to parcellate cortical thickness (CT) and surface area (SA) into genetically homogeneous regions (Chen et al., 2013). In an overlapping twin and sibling sample ( = 834; aged 15-29, 66% female), in those with anxiety-depression Somatic and Psychological Health Report (SPHERE) scores (Hickie et al., 2001) above median, we found a reduction of SA in an occipito-temporal cluster, which comprised part of the right lingual, fusiform and parahippocampal gyrii. A similar reduction was observed in the Human Connectome Project (HCP) sample ( = 890, age 22-37, 56.5% female) in those with Adult Self Report (ASR) DSM-oriented scores (Achenbach et al., 2005) in the 25-95% quantiles. A vertex-wise analysis identified the right lingual and, to a lesser extent the fusiform gyrus. Overall, the surface reduction explained by the anxiety-depression scores was modest ( = -0.10, 3rd order spline, and = -0.040, 1st order spline in the HCP). The discordant results in the top 5% of the anxiety-depression scores may be explained by differences in recruitment between the studies. However, we could not conclude whether this cortical region was an endophenotype for anxiety-depression as the genetic correlations did not reach significance, which we attribute to the modest effect size ( statistical power <10%).

Download full-text PDF

Source
http://dx.doi.org/10.1523/ENEURO.0153-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773884PMC
January 2019
8 Reads

Publication Analysis

Top Keywords

anxiety-depression scores
8
surface area
8
gyrus surface
8
genetic correlations
8
order spline
8
anxiety-depression
6
2001 median
4
median reduction
4
1st order
4
hickie 2001
4
scores hickie
4
reduction occipito-temporal
4
spline hcp
4
comprised lingual
4
fusiform parahippocampal
4
spline -0040
4
parahippocampal gyrii
4
lingual fusiform
4
hcp discordant
4
occipito-temporal cluster
4

Similar Publications