Two-Photon-Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment.

Authors:
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Jeffrey I Zink
Jeffrey I Zink
University of California
United States
Laurence Raehm
Laurence Raehm
Institut Charles Gerhardt Montpellier
Montpellier | France

Adv Healthc Mater 2018 Apr 18;7(7):e1701248. Epub 2018 Jan 18.

Institut Charles Gerhardt de Montpellier, UMR 5253 CNRS-UM-ENSCM, Université de Montpellier, Place Eugène Bataillon, 34095, Montpellier, Cedex 05, France.

Article Synopsis

Two‐photon‐absorbing (2hνA) nanoparticles give more secure malignant growth treatment openings than current treatments lacking spatial and fleeting selectivity on account of their 3D spatial goals and low dissipating. Jonas G. Croissant and co‐workers portray permeable and nonporous 2hνA silica, organosilica, and gold‐silica nanoparticles for bio‐imaging, sedate conveyance, and photodynamic treatment by means of photolysis, vitality exchange, and electron exchange systems.

Patients enduring pathologies, for example, retinoblastoma, breast, and skin malignancies will benefit by TPE‐NIR ultrasensitive finding and treatment.

Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy. Organosilica nanoparticles and their rich and well-established chemistry, tunable composition, porosity, size, and morphology provide ideal platforms for minimal side-effect therapies via TPE-NIR. Mesoporous silica and organosilica nanoparticles endowed with high surface areas can be functionalized to carry hydrophobic and biologically unstable two-photon absorbers for drug delivery and diagnosis. Currently, most light-actuated clinical therapeutic applications with NPs involve photodynamic therapy by singlet oxygen generation, but low photosensitizing efficiencies, tumor resistance, and lack of spatial resolution limit their applicability. On the contrary, higher photosensitizing yields, versatile therapies, and a unique spatial resolution are available with engineered two-photon-sensitive organosilica particles that selectively impact tumors while healthy tissues remain untouched. Patients suffering pathologies such as retinoblastoma, breast, and skin cancers will greatly benefit from TPE-NIR ultrasensitive diagnosis and therapy.

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April 2018
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