Ectopic Cushing's syndrome secondary to olfactory neuroblastoma.

Acta Neurochir (Wien) 2018 05 17;160(5):1023-1026. Epub 2018 Jan 17.

Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, M6 8HD, UK.

We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient's cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB.

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http://dx.doi.org/10.1007/s00701-017-3447-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897482PMC
May 2018
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