Persistent activity in a recurrent circuit underlies courtship memory in .

Authors:
Dr. XiaoLiang Zhao, PhD
Dr. XiaoLiang Zhao, PhD
Janelia Research Campus, HHMI
Research Specialist
Neurobiology
Ashburn, VIRGINIA | United States
Ugur Dag
Ugur Dag
Janelia Research Campus
Barry J Dickson
Barry J Dickson
Research Institute of Molecular Pathology
Austria
Krystyna Keleman
Krystyna Keleman
Research Institute of Molecular Pathology
Austria

Elife 2018 01 11;7. Epub 2018 Jan 11.

Janelia Research Campus, Ashburn, United States.

Recurrent connections are thought to be a common feature of the neural circuits that encode memories, but how memories are laid down in such circuits is not fully understood. Here we present evidence that courtship memory in relies on the recurrent circuit between mushroom body gamma (MBγ), M6 output, and aSP13 dopaminergic neurons. We demonstrate persistent neuronal activity of aSP13 neurons and show that it transiently potentiates synaptic transmission from MBγ>M6 neurons. M6 neurons in turn provide input to aSP13 neurons, prolonging potentiation of MB>M6 synapses over time periods that match short-term memory. These data support a model in which persistent aSP13 activity within a recurrent circuit lays the foundation for a short-term memory.

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http://dx.doi.org/10.7554/eLife.31425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800849PMC
January 2018
12 Reads
3 Citations
8.520 Impact Factor

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