Quantification of Macular Vascular Density Using Optical Coherence Tomography Angiography and Its Relationship with Retinal Thickness in Myopic Eyes of Young Adults.

Authors:
Shiqi Yang
Shiqi Yang
State Key Laboratory of Ophthalmology
Minwen Zhou
Minwen Zhou
Zhongshan Ophthalmic Center
Bing Lu
Bing Lu
Brigham and Women's Hospital
Boston | United States
Pengfei Zhang
Pengfei Zhang
College of Animal Science and Technology
United States
Jingke Zhao
Jingke Zhao
Shanghai General Hospital
Shanghai | China
Mei Kang
Mei Kang
West China Hospital
Nanchong Shi | China
Ruoshi Wang
Ruoshi Wang
State Key Laboratory of Urban and Regional Ecology
Fenghua Wang
Fenghua Wang
Shanghai First People's Hospital
China

J Ophthalmol 2017 29;2017:1397179. Epub 2017 Nov 29.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Purpose: To quantify macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its relationship with retinal thickness in myopic eyes of young adults.

Methods: In this cross-sectional study, 268 myopic eyes without pathological changes were recruited and divided into three groups: mild myopia ( = 81), moderate myopia ( = 117), and high myopia ( = 70). Macular vascular density was quantified by OCTA and compared among three groups. Average retinal thickness, central subfield thickness, and macular ganglion cell complex (mGCC) thickness were also evaluated and compared. Correlations among these variables were analyzed.

Results: There was no statistical difference in superficial (62.3 ± 5.7% versus 62.7 ± 5.9% versus 63.8 ± 5.5%) and deep macular vascular densities (58.3 ± 9.6% versus 59.2 ± 9.3% versus 60.9 ± 7.9%) among mild-myopia, moderate-myopia, and high-myopia groups (both > 0.05). Superficial and deep macular vascular densities both had correlations with mean arterial pressure. Furthermore, superficial macular vascular density was significantly correlated with mGCC thickness.

Conclusions: Varying degrees of myopia did not affect macular vascular density in young healthy adults. In addition, superficial macular vascular density, as an independent factor, was positively correlated with mGCC thickness.

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Source
http://dx.doi.org/10.1155/2017/1397179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727759PMC
November 2017
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