Dual Ligand-Enabled Nondirected C-H Olefination of Arenes.

Angew Chem Int Ed Engl 2018 02 26;57(9):2497-2501. Epub 2018 Jan 26.

Max Planck Institute for Chemical Energy Conversion, Stiftstrasse 34-36, 45470, Mülheim an der Ruhr, Germany.

The application of the Pd-catalyzed oxidative C-H olefination of arenes, also known as the Fujiwara-Moritani reaction, has traditionally been limited by the requirement for directing groups on the substrate or the need to use the arene in large excess, typically as a (co)solvent. Herein the development of a catalytic system is described that, through the combined action of two complementary ligands, makes it possible to use directing-group-free arenes as limiting reagents for the first time. The reactions proceed under a combination of both steric and electronic control and enable the application of this powerful reaction to valuable arenes, which cannot be utilized in excess.

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http://dx.doi.org/10.1002/anie.201712235DOI Listing
February 2018
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