Polymorphisms in oxidative pathway related genes and susceptibility to inflammatory bowel disease.

World J Gastroenterol 2017 Dec;23(47):8300-8307

Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, P.T.S. Granada 18016, Spain.

Aim: To investigate whether common variants in the oxidative pathway genes influence inflammatory bowel disease (IBD) risk among Moroccan patients.

Methods: The distribution of (TAAA)n_rs12720460 and (CCTTT)n _rs3833912 microsatellite repeats, -_rs11549467 and -94ins/delATTG_rs28362491 was analyzed in 507 subjects grouped in 199 IBD and 308 healthy controls. Genotyping was performed with polymerase chain reaction-fluorescent method and the TaqMan allelic discrimination technology.

Results: The allele and genotype frequencies of _ rs11549467, _rs28362491 and _ (TAAA)n did not differ significantly between patients and controls. Analysis of _ (CCTTT)n markers evidenced differences between patients and healthy controls. A preferential presence of the (CCTTT)8 ( = 0.02; OR = 1.71, 95%CI: 1.07-2.74), (CCTTT)14 ( = 0.02; OR = 1.71, 95%CI: 1.06-2.76) alleles in IBD, (CCTTT)8 ( = 0.008; OR = 1.95, 95%CI: 1.17-3.23) in CD and (CCTTT)7 ( = 0.009; OR = 7.61, 95%CI: 1.25-46.08), (CCTTT)11 ( = 0.05; OR = 0.51, 95%CI: 0.25-1.01), (CCTTT)14 ( = 0.02; OR = 2.05, 95%CI: 1.07-3.94), (CCTTT)15 ( = 0.01; OR = 2.25, 95%CI: 1.16-4.35) repeats in UC patients indicated its possible association with higher disease risk which need to be confirmed in a larger sample size.

Conclusion: Our results suggest that the _ (CCTTT)n gene variations may influence IBD susceptibility in the Moroccan population.

Download full-text PDF

Source
http://dx.doi.org/10.3748/wjg.v23.i47.8300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743501PMC
December 2017
5 Reads

Publication Analysis

Top Keywords

bowel disease
8
171 95%ci
8
healthy controls
8
002 171
8
ccttt14 002
8
inflammatory bowel
8
pathway genes
8
oxidative pathway
8
95%ci
7
195 95%ci
4
95%ci 117-323
4
preferential presence
4
presence ccttt8
4
ccttt8 002
4
95%ci 107-274
4
107-274 ccttt14
4
alleles ibd
4
ibd ccttt8
4
106-276 alleles
4
95%ci 106-276
4

References

(Supplied by CrossRef)

Similar Publications