The perivascular origin of pathological fibroblasts.

J Clin Invest 2018 01 2;128(1):54-63. Epub 2018 Jan 2.

The ability to repair tissues is essential for the survival of organisms. In chronic settings, the failure of the repair process to terminate results in overproduction of collagen, a pathology known as fibrosis, which compromises organ recovery and impairs function. The origin of the collagen-overproducing cell has been debated for years. Here we review recent insights gained from the use of lineage tracing approaches in several organs. The resulting evidence points toward specific subsets of tissue-resident mesenchymal cells, mainly localized in a perivascular position, as the major source for collagen-producing cells after injury. We discuss these findings in view of the functional heterogeneity of mesenchymal cells of the perivascular niche, which have essential vascular, immune, and regenerative functions that need to be preserved for efficient repair.

Download full-text PDF

Source
https://www.jci.org/articles/view/93558
Publisher Site
http://dx.doi.org/10.1172/JCI93558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749494PMC
January 2018

Publication Analysis

Top Keywords

mesenchymal cells
8
collagen-overproducing cell
4
findings view
4
origin collagen-overproducing
4
cell debated
4
debated years
4
injury discuss
4
years review
4
function origin
4
discuss findings
4
view functional
4
heterogeneity mesenchymal
4
compromises organ
4
cells perivascular
4
organ recovery
4
perivascular position
4
impairs function
4
recovery impairs
4
review insights
4
gained lineage
4

Similar Publications