[Atezolizumab (Tecentriq): Activity, indication and modality of use in advanced or metastatic urinary bladder carcinoma].

Bull Cancer 2018 Feb 28;105(2):140-145. Epub 2017 Dec 28.

University of Paris Sud, Gustave Roussy cancer campus, drug development department, 94805 Villejuif cedex, France; University of Paris Sud, Gustave Roussy cancer campus, department of medical oncology, 94805 Villejuif cedex, France. Electronic address:

Treatments for patients with metastatic or advanced urothelial carcinomas on progression after first line chemotherapy or unfit for cisplatin are currently limited. Atezolizumab (Tecentriq) is a monoclonal antibody targeting PD-L1. The first of IMVIGOR 210 phase II trial (NCT02951767) investigated atezolizumab as front line treatment among 119 patients with metastatic urothelial cancer unfit for cisplatin. Response rate was 23% and median overall survival 15.9 months. The second cohort (NCT02108652) included 310 patients whose tumors were progressing after first line platinum-based chemotherapy. Response rate was 15% and median overall survival 7.9 months. Among patients with high PD-L1 expression on infiltrating immune cells (ICs), response rate was 26% and median overall survival 11 months. Atezolizumab was well-tolerated in both cohorts with 66% of treatment-related toxicities including 12% (cohort 1) and 7% (cohort 2) of grade 3-4 adverse events. These results led to an approval by the FDA in United States and the EMA in Europe. In France, atezolizumab was available through an early access agreement by the French National Agency for Medicines and Health Products (ANSM) for patients with metastatic or advanced urothelial carcinomas on progression after first line chemotherapy or unfit for cisplatin. So far, its avaibility in France within the EMA approval is pending its pricing.

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00074551173038
Publisher Site
http://dx.doi.org/10.1016/j.bulcan.2017.10.030DOI Listing
February 2018
20 Reads

Publication Analysis

Top Keywords

median survival
12
response rate
12
patients metastatic
12
unfit cisplatin
12
urothelial carcinomas
8
carcinomas progression
8
progression chemotherapy
8
advanced urothelial
8
metastatic advanced
8
survival months
8
chemotherapy unfit
8
patients
5
included 310
4
patients tumors
4
310 patients
4
france atezolizumab
4
chemotherapy response
4
rate 15%
4
15% median
4
platinum-based chemotherapy
4

Similar Publications