Cell Biol Int 2017 Dec 29. Epub 2017 Dec 29.
Department of Medical Oncology, First People's Hospital of Yunnan Province, No. 157 of Jinbi Road, Xishan district of Kunming City, Yunnan Province, P. R. China.
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Diagn Pathol 2015 Jul 25;10:127. Epub 2015 Jul 25.
TCM-Integrated Hospital, Southern Medical University, Cancer Center, NO.13 Shiliugang Road, Haizhu District, Guangzhou, Guangdong, 510315, China.
Background: The microRNAs present a class of non-coding RNAs which are usually implicated in tumor biology. Recent report has unraveled that a novel member of microRNA family called miR-1246. However, the functional role and molecular mechanisms of miR-1246 in non-small cell lung cancer (NSCLC) is still elusive. Read More
Biochem Biophys Res Commun 2017 07 20;489(2):135-141. Epub 2017 May 20.
Department of General Surgery, Qilu Hospital of Shandong University, 107 Wen Hua Xi Road, Jinan, Shandong 250012, PR China. Electronic address:
Cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a member of CPEB family which is overexpressed in variety of cancers. However, the biological role and regulatory mechanism of CPEB4 in cancers remain unknown. Here, we first investigate the role of CPEB4 in breast cancer progression and metastasis. Read More
Oncol Lett 2014 Nov 20;8(5):2063-2068. Epub 2014 Aug 20.
Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Accumulating evidence has revealed that an elevated expression level of Aurora-B is associated with metastasis in various types of malignant tumor. However, it is currently unclear whether this molecule is involved in non-small lung cancer (NSCLC) metastasis, and the molecular mechanisms associated with Aurora-B and metastasis remain unknown. In the present study, in order to investigate whether Aurora-B is involved in the development and metastasis of NSCLC, the Aurora-B protein expression in NSCLC tissues was detected by immunohistochemistry and its association with metastasis was analyzed. Read More
Cell Physiol Biochem 2017 17;42(4):1431-1446. Epub 2017 Jul 17.
Department of thoracic surgery, Dongying, China.
Objective: This study explored the ability of microRNA-135a (miR-135a) to influence cell proliferation, migration, invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer (NSCLC).
Methods: NSCLC tissues and adjacent normal tissues were collected from 138 NSCLC patients. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression levels of miR-135a and IGF-1, PI3K, Akt, VEGF, bFGF and IL-8 mRNA; western blotting was used to determine the expression levels of IGF-1, PI3K and Akt protein; and enzyme-linked immunosorbent assay (ELISA) was used to analyze the expression levels of VEGF, bFGF and IL-8 protein. Read More