Stem cell therapy in necrotizing enterocolitis: Current state and future directions.

Semin Pediatr Surg 2018 Feb 7;27(1):57-64. Epub 2017 Nov 7.

Department of Surgery, Section of Pediatric Surgery, Indiana University School of Medicine, Riley Hospital for Children at IU Health, 705 Riley Hospital Dr. RI 2500, Indianapolis, Indiana 46202. Electronic address:

Stem cell therapy is a promising treatment modality for necrotizing enterocolitis. Among the many promising stem cells identified to date, it is likely that mesenchymal stem cells will be the most useful and practical cell-based therapies for this condition. Using acellular components such as exosomes or other paracrine mediators are promising as well. Multiple mechanisms are likely at play in the positive effects provided by these cells, and further research is underway to further elucidate these effects.

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http://dx.doi.org/10.1053/j.sempedsurg.2017.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745058PMC
February 2018
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