Cell Biol Int 2018 Jun 22;42(6):651-655. Epub 2018 Jan 22.
Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, São Paulo, Brazil.
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Clin Sci (Lond) 2017 Jun;131(12):1329-1342
School of Biomedical Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Perth, WA, Australia
In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities and consumption and production levels of metabolites in incubated or cultured macrophages isolated from the mouse or rat intraperitoneal cavity. Read More
J Clin Cell Immunol 2015 Dec 30;6(6). Epub 2015 Nov 30.
Department of Medicine, University of Alabama at Birmingham, Alabama, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Alabama, USA; Birmingham VAMC, Birmingham, Alabama, USA.
Macrophage plasticity is an important feature of these innate immune cells. Macrophage phenotypes are divided into two categories, the classically activated macrophages (CAM, M1 phenotype) and the alternatively activated macrophages (AAM, M2 phenotype). M1 macrophages are commonly associated with the generation of proinflammatory cytokines, whereas M2 macrophages are anti-inflammatory and often associated with tumor progression and fibrosis development. Read More
Immunology 2018 Mar 26;153(3):342-356. Epub 2017 Oct 26.
Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven - University of Leuven, Leuven, Belgium.
Macrophage activation is characterized by pronounced metabolic adaptation. Classically activated macrophages show decreased rates of mitochondrial fatty acid oxidation and oxidative phosphorylation and acquire a glycolytic state together with their pro-inflammatory phenotype. In contrast, alternatively activated macrophages require oxidative phosphorylation and mitochondrial fatty acid oxidation for their anti-inflammatory function. Read More
J Mol Med (Berl) 2014 Nov 25;92(11):1119-28. Epub 2014 Jun 25.
Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Metabolism and defense mechanisms that protect against pathogens are two fundamental requirements for the survival of multicellular organisms. Research into metabolic disease has revealed these core mechanisms are highly co-dependent. This emerging field of research, termed immunometabolism, focuses on understanding how metabolism influences immunological processes and vice versa. Read More