Cleve Clin J Med 2017 Dec;84(12 Suppl 3):39-46
Section Head, Department of Vascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.
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Cardiol Clin 2015 Feb;33(1):49-57
Department of Surgery, Jefferson Vascular Center, Thomas Jefferson University Hospitals, 111 South 11th Street, Philadelphia, PA 19107, USA.
Venous thromboembolism (VTE) is a potentially fatal condition and includes deep vein thrombosis and pulmonary embolism. The novel oral anticoagulants, which include the direct thrombin and factor Xa inhibitors, have been shown to be safe and effective for the treatment of VTE. Additional interventions include thrombolysis and the use of inferior vena cava filters. Read More
J Thromb Haemost 2017 Aug;15(8):1531-1540
Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.
Venous thromboembolism (VTE) is a common disease (~700 per 100 000) that is associated with significant risk of recurrence, chronic complications, and substantial mortality, with reported death rates of up to 40% at 10 years. The development of novel anticoagulants has revolutionized the treatment of acute VTE, while strategies for prevention and treatment of chronic complications still seek for such a landmark change. Impaired thrombus resolution is the common denominator behind VTE complications, which are postthrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (CTEPH). Read More
Thromb Haemost 2009 Oct;102(4):688-93
Department of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Long-term complications from hospital-acquired acute venous thromboembolism (VTE) include recurrent VTE, postthrombotic syndrome (PTS), and chronic thromboembolic pulmonary hypertension (CTEPH). We used a probability model to estimate the number of these events among hospitalised medical patients in the 2003 United States Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample database. Of 8,077,919 hospitalised medical patients at risk for VTE, we calculate that 122,235 were stricken with deep vein thrombosis (DVT) and 32,654 with pulmonary embolism (PE). Read More
Mayo Clin Proc 2014 Mar;89(3):394-408
Division of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address:
Venous thromboembolism is a major source of morbidity and mortality in the United States. The American College of Chest Physicians Antithrombotic Guidelines, 9th edition, includes a large number of clinical practice recommendations regarding the diagnosis, treatment, and prevention of venous thromboembolism. This succinct clinical review of these guidelines specifically focuses on the evaluation, treatment, and prevention of venous thromboembolic disease. Read More