Ovarian cancer risk, ALDH2 polymorphism and alcohol drinking: Asian data from the Ovarian Cancer Association Consortium.

Authors:
Tomotaka Ugai
Tomotaka Ugai
Jichi Medical University
Japan
Linda E Kelemen
Linda E Kelemen
Medical University of South Carolina
Charleston | United States
Mika Mizuno
Mika Mizuno
Nagoya University Graduate School of Medicine
Japan
Penelope M Webb
Penelope M Webb
QIMR Berghofer Medical Research Institute
Brisbane City | Australia
Kristine G Wicklund
Kristine G Wicklund
Fred Hutchinson Cancer Research Center
Seattle | United States

Cancer Sci 2018 Feb 21;109(2):435-445. Epub 2018 Jan 21.

Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.

The aldehyde dehydrogenase 2 (ALDH2) polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1274 controls of Asian descent with information on recent alcohol consumption. Pooled odds ratios (OR) with 95% confidence intervals (CI) for OvCa risk associated with alcohol consumption, rs671 and their interaction were estimated using logistic regression models adjusted for potential confounders. No significant association was observed for daily alcohol intake with invasive OvCa (OR comparing any consumption to none = 0.83; 95% CI = 0.58-1.18) or with individual histotypes. A significant decreased risk was seen for carriers of one or both Lys alleles of rs671 for invasive mucinous OvCa (OR = 0.44; 95% CI = 0.20-0.97) and for invasive and borderline mucinous tumors combined (OR = 0.48; 95% CI = 0.26-0.89). No significant interaction was observed between alcohol consumption and rs671 genotypes. In conclusion, self-reported alcohol consumption at the quantities estimated was not associated with OvCa risk among Asians. Because the rs671 Lys allele causes ALDH2 inactivation leading to increased acetaldehyde exposure, the observed inverse genetic association with mucinous ovarian cancer is inferred to mean that alcohol intake may be a risk factor for this histotype. This association will require replication in a larger sample.

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Source
http://dx.doi.org/10.1111/cas.13470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797830PMC
February 2018
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