Cleve Clin J Med 2017 Dec;84(12):918
Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
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Am J Gastroenterol 1996 Apr;91(4):802-4
First Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
A 79-year-old woman was admitted to our hospital with complaints of dysphagia and multiple verrucous papules that had developed over the previous year. The diagnosis of esophageal carcinoma was based on upper gastrointestinal radiography and endoscopic examination with biopsy. The clinical syndrome was consistent with the sign of Leser-Trelat associated with esophageal carcinoma. Read More
Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):112
Department of Dermatology, Venereology and Leprology, Government Medical College, Kota, Rajasthan, India.
J Am Acad Dermatol 2000 Aug;43(2 Pt 2):386-90
Department of Dermatology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
This is what we believe to be the first report of the sign of Leser-Trélat in association with occult adenocarcinoma of the lung. The sign of Leser-Trélat is proposed as a sign of possible occult malignancy, despite various suggestions to the contrary. Also, it is suggested that a tumor-produced humoral factor (eg, transforming growth factor-alpha [TGF-alpha]) could be responsible for both the acute eruption of the monomorphous seborrheic keratoses and the nearly concomitant development of acanthosis nigricans, which occurred in our case. Read More
Am Fam Physician 1995 Jun;51(8):1825, 1830