Neuroleptic malignant syndrome as a presenting feature of subacute sclerosing panencephalitis.

Authors:
Divyani Garg
Divyani Garg
All India Institute of Medical Sciences
New Delhi | India
Varun Reddy
Varun Reddy
University Park
United States
Rajesh Kumar Singh
Rajesh Kumar Singh
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Germany
Deepa Dash
Deepa Dash
All India Institute of Medical Sciences
Rohit Bhatia
Rohit Bhatia
All India Institute of Medical Sciences
India
Manjari Tripathi
Manjari Tripathi
All India Institute of Medical Sciences
India

J Neurovirol 2018 Feb 14;24(1):128-131. Epub 2017 Dec 14.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with raised titres of anti-measles antibodies in CSF and serum. Atypical presentations of SSPE have been reported including brainstem involvement, ADEM-like presentation, acute encephalitis, and cerebellar ataxia. Presentation with predominant extrapyramidal features is uncommon. We describe a case of SSPE presenting with extensive rigidity with highly elevated CPK values, mimicking neuroleptic malignant syndrome (NMS) which was most probably due to central dopaminergic blockade induced by the disease process. To our knowledge, this is the first case of SSPE presenting with a NMS-like syndrome.

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http://dx.doi.org/10.1007/s13365-017-0602-4DOI Listing
February 2018
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