Chin J Physiol 2017 Dec;60(6):320-326
Community Medicine Research Center, Keelung Chang Gung Memorial Hospital, Keelung 20445, Taiwan, ROC.
Few diagnostic biomarkers for sepsis after emergency peritonitis surgery are available to
clinicians, and, thus, it is important to develop new biomarkers for patients undergoing this procedure.
We investigated whether serum glutamine and selenium levels could be diagnostic biomarkers of sepsis
in individuals recovering from emergency peritonitis surgery. From February 2012 to March 2013,
patients who had peritonitis diagnosed at the emergency department and underwent emergency
surgery were screened for eligibility. Serum glutamine and selenium levels were obtained at pre-operative,
post-operative and recovery time points. The average level of pre-operation serum glutamine was
significantly different from that on the recovery day (0.317 ± 0.168 vs. 0.532 ± 0.155 mM, P < 0.001);
moreover, serum glutamine levels were unaffected by surgery. Selenium levels were significantly
lower on the day of surgery than they were at recovery (106.6 ± 36.39 vs. 130.68 ± 56.98 ng/mL, P = 0.013);
no significant difference was found between pre-operation and recovery selenium levels. Unlike
selenium, glutamine could be a sepsis biomarker for individuals with peritonitis. We recommend
including glutamine as a biomarker for sepsis severity assessment in addition to the commonly used