Risk Stratification for Prevention of Recurrence of Postoperative Crohn's Disease.

Authors:
Yecheskel Schneider
Yecheskel Schneider
Division of Gastroenterology and Hepatology
Stephanie Gold
Stephanie Gold
Hospital for Special Surgery
United States
Ellen Scherl
Ellen Scherl
Cornell University
United States
Adam Steinlauf
Adam Steinlauf
Mount Sinai Hospital
United States

Gastroenterol Hepatol (N Y) 2017 Nov;13(11):651-658

Dr Cohen-Mekelburg and Dr Schneider are gastroenterology fellows, Dr Gold is an internal medicine resident, Dr Scherl is a clinical professor and attending physician, and Dr Steinlauf is an assistant professor and attending physician at NewYork-Presbyterian/Weill Cornell Medical Center in New York, New York.

Although there have been significant advances in medical therapies to treat Crohn's disease, an estimated 50% of patients will require surgery within the first decade of disease duration. Of these patients, a substantial number will develop recurrent symptoms within the first postoperative year. To prevent disease recurrence, many physicians use postoperative prophylactic therapy. Randomized, controlled trials, although limited in number, have demonstrated that a prophylactic postoperative strategy is effective at reducing recurrence (both clinical and endoscopic) in high-risk patients. This article reviews the frequency of and risk factors for postoperative Crohn's disease recurrence and the current evidence in favor of postoperative Crohn's disease management strategies. Future studies must be conducted to establish a gold standard as to who should receive postoperative prophylaxis and which therapies and time course are ideal.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5717880PMC

Still can't find the full text of the article?

We can help you send a request to the authors directly.
November 2017
19 Reads

Publication Analysis

Top Keywords

crohn's disease
16
postoperative crohn's
12
disease recurrence
8
postoperative
7
disease
6
strategy effective
4
prophylactic postoperative
4
postoperative strategy
4
effective reducing
4
recurrence clinical
4
high-risk patients
4
patients article
4
endoscopic high-risk
4
clinical endoscopic
4
demonstrated prophylactic
4
reducing recurrence
4
controlled trials
4
physicians postoperative
4
recurrence physicians
4
prevent disease
4

Similar Publications