A 5-year multicenter prospective cohort study on the long-term visual prognosis and predictive factors for visual outcome in Japanese patients with age-related macular degeneration: the AMD2000 study.

Authors:
Akitaka Tsujikawa
Akitaka Tsujikawa
Kyoto University Graduate School of Medicine
Japan
Tatsuro Ishibashi
Tatsuro Ishibashi
Kyushu University
Japan
Hideo Nakanishi
Hideo Nakanishi
Kyoto University Graduate School of Medicine
Japan
Dr. Eiji Nakatani, PhD
Dr. Eiji Nakatani, PhD
Division of Statistical Analysis, Research Support Center, Shizuoka General Hospital
division chair
Biostatistics
Shizuoka, Shizuoka | Japan
Satoshi Teramukai
Satoshi Teramukai
Graduate School of Medical Science
Japan
Masanori Fukushima
Masanori Fukushima
Translational Research Informatics Center

Jpn J Ophthalmol 2018 Mar 9;62(2):137-143. Epub 2017 Dec 9.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: In this study (AMD2000), we aimed to determine the visual prognosis of Japanese patients with age-related macular degeneration (AMD).

Methods: This was a multicenter prospective observational cohort study. In total, 460 patients with AMD were recruited from April 2006 to March 2009 from 18 clinical trial sites in Japan. They were followed up for 5 years, as they continued to receive medical treatment.

Results: Of the 409 study eyes followed up for at least 1 year, 243 eyes (59.4%) were treated with photodynamic therapy (PDT) using verteporfin, and 58 eyes (14.2%) were treated with intravitreal injections of antivascular endothelial growth factor agents as the initial treatment. The mean best-corrected visual acuities (BCVA) for typical AMD (tAMD; 0.688 ± 0.498) and polypoidal choroidal vasculopathy (PCV; 0.451 ± 0.395) were significantly less at 2 years (tAMD, 0.779 ± 0.632, P < 0.05; PCV, 0.534 ± 0.618, P < 0.05) and at 5 years (AMD, 0.873 ± 0.718, P < 0.05; PCV, 0.635 ± 0.668, P < 0.05) than at baseline. In eyes with tAMD, absence of blocked fluorescence was associated with 5-year maintenance of the baseline BCVA. Regarding PCV, the presence of polypoidal lesions and cystoid macular edema as well as the lesion size was associated with 5-year maintenance of the baseline BCVA. In some patients, the diagnosis changed: of the 192 eyes initially diagnosed with typical AMD, 19 were newly diagnosed with PCV during follow-up.

Conclusion: Maintaining the baseline BCVA over the long term is difficult in Japanese eyes with wet AMD.

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http://dx.doi.org/10.1007/s10384-017-0554-5DOI Listing
March 2018
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References

(Supplied by CrossRef)
Article in Lancet Glob Health
WL Wong et al.
Lancet Glob Health 2014
Article in Clin Ophthalmol.
RP Danis et al.
Clin Ophthalmol. 2015
Article in Prog Retin Eye Res.
CW Wong et al.
Prog Retin Eye Res. 2016
Article in Am J Ophthalmol.
A Oishi et al.
Am J Ophthalmol. 2015
Article in Jpn J Ophthalmol.
M Saito et al.
Jpn J Ophthalmol. 2017
Article in Jpn J Ophthalmol.
M Hosokawa et al.
Jpn J Ophthalmol. 2017
Article in Surv Ophthalmol.
AC Bird et al.
Surv Ophthalmol. 1995
Article in Optom Vis Sci.
J Zhang et al.
Optom Vis Sci. 2015
Article in Br J Ophthalmol.
O Semoun et al.
Br J Ophthalmol. 2016
Article in Retina.
LA Yannuzzi et al.
Retina. 1990
Article in Am J Ophthalmol.
H Iijima et al.
Am J Ophthalmol. 1999

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