Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    [Neuroleptic malignant syndrome].

    Nervenarzt 2017 Dec 5. Epub 2017 Dec 5.
    Klinische Pharmakologie am Lehrstuhl für Pharmakologie und Toxikologie, Universität Regensburg, Regensburg, Deutschland.
    Background: Neuroleptic malignant syndrome (NMS) is a rare but severe undesired complication of psychopharmacological treatment. The mortality has shown a significant decrease since its first description. Knowledge of NMS is important for every clinician because of the need for rapid diagnosis and treatment.

    Objective: This article presents a review and critical appraisal of the current study situation for NMS. Recommendations for diagnostics, differential diagnostics and treatment are presented particularly from a clinical perspective.

    Material And Methods: A literature review with the keywords "neuroleptic malignant syndrome", "Malignes neuroleptisches Syndrom" and various psychotropic drugs was performed in PubMed. The database of the Working Group for Pharmaceutical Treatment of Psychiatric Diseases (Arbeitsgemeinschaft für Arzneimitteltherapie bei psychiatrischen Erkrankungen, AGATE) was analyzed with respect to registered cases of the undesired side effect NMS.

    Results: In contrast to the first description, which also led to the name, there are now case reports of clinical conditions similar to NMS, which were obviously triggered by several groups of psychotropic drugs not just antipsychotic agents (German: Neuroleptika). Treatment recommendations exist whereby the effectiveness cannot always be scientifically substantiated; however, it is still undisputed that a rapid initiation of treatment is of great importance.

    Discussion: The psychiatrist must be familiar with the symptoms of NMS, its differential diagnosis and the therapeutic options for a rapid and effective treatment. Further studies are urgently needed for scientific substantiation of the pathophysiology of NMS and to develop evidence-based guidelines for treatment.
    PDF Download - Full Text Link
    ( Please be advised that this article is hosted on an external website not affiliated with PubFacts.com)
    Source Status
    http://dx.doi.org/10.1007/s00115-017-0463-3DOI ListingPossible

    Similar Publications

    [Case report: Neuroleptic malignant syndrome and diagnostic difficulties].
    Encephale 2016 Jun 26;42(3):277-80. Epub 2016 Feb 26.
    Pôle Santé Publique, Pharmacovigilance, CHU Grenoble-Alpes, 38000 Grenoble, France.
    Background: Neuroleptic malignant syndrome (NMS) is an uncommon but potentially fatal adverse effect of neuroleptic drugs. It is commonly characterized by muscular rigidity, fever, altered mental status, and autonomic dysfunction. Emerging of NMS is possible with all neuroleptics, classic and atypical. Read More
    [Neuroleptic malignant syndrome and atypical antipsychotics: a brief review].
    Encephale 2008 Dec 2;34(6):618-24. Epub 2008 Apr 2.
    Background: Neuroleptic malignant syndrome (NMS) is an uncommon, but potentially life threatening complication of neuroleptic drugs. In 1960, Delay et al. [Ann Med Psychol 118 (1960) 145-152] described the "syndrome akinétique hypertonique"(hypertonic akinetic syndrome) and its cardinal symptoms: hyperthermia, extrapyramidal symptoms, altered mental status and autonomic dysfunctions. Read More
    [The Neuroleptic Malignant Syndrome].
    Fortschr Neurol Psychiatr 2015 Jul 22;83(7):373-80. Epub 2015 Jul 22.
    Psychiatrie, Universität Lübeck.
    Background: Neuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening medication-induced syndrome. Core symptoms are hyperthermia, diaphoresis, rigidity, impaired consciousness, and creatinine kinase elevation. Additionally, patients show vegetative dysregulation including blood pressure fluctuations. Read More
    Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective.
    Curr Neuropharmacol 2015 ;13(3):395-406
    Non-Invasive Neurostimulation Therapies Laboratory at UBC (NINET), UBC Hospital; Detwiller Pavilion, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1.
    Neuroleptic malignant syndrome (NMS) is a rare but potentially life-threatening side-effect that can occur in response to treatment with antipsychotic drugs. Symptoms commonly include hyperpyrexia, muscle rigidity, autonomic dysfunction and altered mental status. In the current review we provide an overview on past and current developments in understanding the causes and treatment of NMS. Read More