Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs.

Authors:
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy

Oxid Med Cell Longev 2017 22;2017:1089359. Epub 2017 Oct 22.

Dipartimento di Scienze Biomediche Avanzate, Università Federico II di Napoli, via Pansini 5, 80131 Napoli, Italy.

The discovery of the molecular mechanisms involved in the cardiac responses to anticancer drugs represents the current goal of cardio-oncology research. The oxidative stress has a pivotal role in cardiotoxic responses, affecting the function of all types of cardiac cells, and their functional crosstalks. Generally, cardiomyocytes are the main target of research studies on cardiotoxicity, but recently the contribution of the other nonmyocyte cardiac cells is becoming of growing interest. This review deals with the role of oxidative stress, induced by anticancer drugs, in cardiac nonmyocyte cells (fibroblasts, vascular cells, and immune cells). The alterations of functional interplays among these cardiac cells are discussed, as well. These interesting recent findings increase the knowledge about cardiotoxicity and suggest new molecular targets for both diagnosis and therapy.

Download full-text PDF

Source
http://dx.doi.org/10.1155/2017/1089359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671742PMC
July 2018
4 Reads

Publication Analysis

Top Keywords

cardiac cells
12
anticancer drugs
8
oxidative stress
8
cardiac nonmyocyte
8
cells
6
cardiac
6
generally cardiomyocytes
4
cardiomyocytes main
4
main target
4
discussed well
4
studies cardiotoxicity
4
well interesting
4
target studies
4
cells functional
4
interesting findings
4
immune cells
4
cardiotoxic responses
4
function types
4
types cardiac
4
functional crosstalks
4

References

(Supplied by CrossRef)

Similar Publications