Frontal evoked γ activity modulates behavioural performance in Autism Spectrum Disorders in a perceptual simultaneity task.

Neurosci Lett 2018 02 27;665:86-91. Epub 2017 Nov 27.

Department of Psychiatry & Institute of Medical Psychology, Ludwig-Maximilians-Universität, 80336, Munich, Germany; Department of Psychology, University of Cologne, 50931, Cologne, Germany. Electronic address:

Autism spectrum disorders (ASDs) are associated with anomalies in time perception. In a perceptual simultaneity task, individuals with ASD demonstrate superior performance compared to typically developing (TD) controls. γ-activity, a robust marker of visual processing, is reportedly altered in ASD in response to a wide variety of tasks and these differences may be related to superior performance in perceptual simultaneity. Using time-frequency analysis, we assessed evoked γ-band phase-locking in magnetoencephalographic recordings of 16 ASD individuals and 17 age-matched TD controls. Individuals judged whether presented visual stimuli were simultaneous or asynchronous. We identified left frontal γ-activity in ASD, which was associated with a reduced perception of simultaneity. Where feature binding was observed at a neurophysiological level in parieto-occipital cortices in ASD in apparent simultaneity (asynchronous stimuli with short delay between them), this did not predict the correct behavioural outcome. These findings suggest distinct γ profiles in ASD associated with the perception of simultaneity.

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http://dx.doi.org/10.1016/j.neulet.2017.11.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821698PMC
February 2018
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