NLRP10 Enhances CD4 T-Cell-Mediated IFNγ Response Regulation of Dendritic Cell-Derived IL-12 Release.

Front Immunol 2017 2;8:1462. Epub 2017 Nov 2.

Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.

NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a mouse to delineate the role of NLRP10 in the host immune response and found that dendritic cells (DCs) elicited sub-optimal IFNγ production by antigen-specific CD4 T cells compared to wild-type (WT) DCs. In response to T-cell encounter, CD40 ligation or Toll-like receptor 9 stimulation, DCs produced low levels of IL-12, due to a substantial decrease in NF-κB activation. Defective IL-12 production was also evident and affected IFNγ production by CD4 T cells. Upon () infection, mice displayed diminished T helper 1-cell responses and increased bacterial growth compared to WT mice. These data indicate that NLRP10-mediated IL-12 production by DCs is critical for IFNγ induction in T cells and contributes to promote the host defense against .

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2017.01462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673625PMC
November 2017
31 Reads

Publication Analysis

Top Keywords

cd4 cells
8
il-12 production
8
ifnγ production
8
compared wild-type
4
wild-type dcs
4
compared mice
4
cells compared
4
immune response
4
dcs response
4
response t-cell
4
encounter cd40
4
bacterial growth
4
t-cell encounter
4
growth compared
4
antigen-specific cd4
4
production antigen-specific
4
response dendritic
4
cells dcs
4
mice displayed
4
dendritic cells
4

Similar Publications