Transport Characteristics of Asymmetric Cellulose Triacetate Hemodialysis Membranes.

Authors:
Mahsa Hadidi
Mahsa Hadidi
The Pennsylvania State University
State College | United States
Takashi Sunohara
Takashi Sunohara
Nipro Corporation
Doral | United States
Andrew L Zydney
Andrew L Zydney
University Park
United States

Blood Purif 2018 22;45(1-3):46-52. Epub 2017 Nov 22.

Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA.

Aims: The objective of this study was to compare the transport characteristics of highly asymmetric cellulose triacetate (ATA™) membranes with that of both symmetric cellulose triacetate and asymmetric polysulfone membranes.

Methods: Data were obtained for solute clearance and sieving coefficients of vitamin B12 and a range of polydisperse dextrans using ATA™ SOLACEA-25H and Optiflux F250NR polysulfone dialyzers. Results for these, and the CT190 symmetric cellulose triacetate dialyzer, were analyzed using available membrane transport models.

Results: The ATA™ had the largest solute clearance, although the homogeneous CT190 dialyzer had the highest sieving coefficients. These differences were a direct result of the differences in the underlying membrane morphology, with the asymmetric ATA™ membrane providing much higher diffusive transport rates (and thus higher solute clearance).

Conclusions: These results demonstrate the importance of membrane morphology on dialyzer transport and provide important insights into the effective clinical performance observed with the highly asymmetric ATA™ dialyzers.

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November 2017
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