Clinical Benefits of High-Volume Hemofiltration in Critically Ill Pediatric Patients with Severe Sepsis: A Retrospective Cohort Study.

Authors:
Huijie Miao
Huijie Miao
Shanghai Children's Hospital
Fei Wang
Fei Wang
University of Maryland
College Park | United States
Chunxia Wang
Chunxia Wang
Institute for Nutritional Sciences
China
Yucai Zhang
Yucai Zhang
Shanghai Children's Hospital

Blood Purif 2018 22;45(1-3):18-27. Epub 2017 Nov 22.

Department of Critical Care Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Putuo District, Shanghai, China.

Aims: The study aimed to assess the clinical benefits of high-volume hemofiltration (HVHF) in pediatric patients with severe sepsis compared with standard-volume continuous veno-venous hemofiltration (CVVH).

Methods: We retrospectively analyzed the medical records of 155 pediatric patients with severe sepsis admitted to the pediatric intensive care unit of Shanghai Children's Hospital from January 2010 to June 2016. A total of 93 patients were treated with HVHF and 62 patients were treated with CVVH.

Results: HVHF treatment did not significantly reduce 28-day mortality. Moreover, there was no significant difference in reducing the plasma level of inflammatory mediators and improving hemodynamic variables between HVHF and CVVH group. However, the incidence of hyperglycemia was significantly higher in HVHF group than in CVVH group.

Conclusions: There is no evidence to indicate that HVHF is superior to CVVH in reducing 28-day mortality as an adjunct to the treatment of severe sepsis in pediatric patients.

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http://dx.doi.org/10.1159/000481249DOI Listing
November 2017
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