Association between Extreme Values of Markers of Chronic Kidney Disease: Mineral and Bone Disorder and 5-Year Mortality among Prevalent Hemodialysis Patients.

Authors:
Jin-Bor Chen
Jin-Bor Chen
Chang Gung University College of Medicine
Taiwan
Chih-Hsiung Lee
Chih-Hsiung Lee
Chang Gung University College of Medicine
Taiwan
Gang Long
Gang Long
Wuhan Institute of Virology
China

Blood Purif 2018 22;45(1-3):1-7. Epub 2017 Nov 22.

Department of Nephrology, Tianjin Union Medicine Center, Tianjin, PR China.

Background/aims: We examined the association between markers of chronic kidney disease - mineral and bone disorder (CKD-MBD) and mortality in hemodialysis (HD) patients.

Methods: We retrospectively reviewed the association between markers of CKD-MBD and mortality in 1,126 HD patients from 2009 to 2013 with baseline (B), time-average (TA), and time-dependent (TD) Cox regression models.

Results: Hypercalcemia (10.9-11.9 mg/dL) indicated an increased risk of all-cause mortality (TA: hazard ratio [HR] 3.49; p = 0.01). Hypophosphatemia (2.0-2.5 mg/dL) was significantly associated with an increased risk of all-cause mortality (TA: HR 5.18; p = 0.01). Hypophosphatemia (<2.0 mg/dL) was significantly associated with an increased risk of cardiovascular mortality in all models. Intact parathyroid hormone levels <60 and >1,500 pg/mL indicated an increased risk of all-cause mortality (TA: HR 1.64; p = 0.02; TD: HR 2.26; p = 0.02).

Conclusion: Extreme values of CKD-MBD markers are associated with mortality risk in HD patients. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=478972.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000478972DOI Listing

Still can't find the full text of the article?

Sign up to send a request to the authors directly.
November 2017
18 Reads

Publication Analysis

Top Keywords

001 hypophosphatemia
8
markers chronic
8
chronic kidney
8
mineral bone
8
kidney disease
8
bone disorder
8
all-cause mortality
8
ckd-mbd mortality
8
association markers
8
increased risk
8
risk all-cause
8
disease mineral
8
mortality
5
baseline time-average
4
mortality 518
4
time-average time-dependent
4
time-dependent cox
4
regression modelsresults
4
cox regression
4
2013 baseline
4

References

(Supplied by CrossRef)

Similar Publications

Manganese tolerance in Verbascum olympicum Boiss. affecting elemental uptake and distribution: changes in nicotinic acid levels under stress conditions.

Environ Sci Pollut Res Int 2018 Oct 15;25(29):29129-29143. Epub 2018 Aug 15.

Department of Chemistry, Faculty of Arts and Sciences, Bursa Uludag University, Bursa, Turkey.

A multielemental determination methodology in conjunction with an organic acid analysis that were supplemented with other stress parameters and an ultrastructural analysis used herein to study Verbascum olympicum Boiss. (Scrophulariaceae) under Mn stress. Uptake and accumulation characteristics of B, Cu, Fe, Mn, Mo, and Zn were evaluated in 8-week-old seedlings grown in Hoagland's nutrient solution and exposed to 5 (CK), 50, and 200 μM MnSO for 7 days. Read More

View Article
October 2018
23 Reads
2.83 Impact Factor

KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome.

Am J Med Genet A 2018 Jul 7;176(7):1602-1609. Epub 2018 May 7.

Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs (MNGHA), Riyadh, Saudi Arabia.

Intellectual disability (ID) and global developmental delay are closely related; the latter is reserved for children under the age of 5 years as it is challenging to reliably assess clinical severity in this population. ID is a common condition, with up to 1%-3% of the population being affected and leading to a huge social and economic impact. ID is attributed to genetic abnormalities most of the time; however, the exact role of genetic involvement in ID is yet to be determined. Read More

View Article
July 2018
112 Reads
2.16 Impact Factor

Factors associated with diarrheal morbidity among under-five children in Jigjiga town, Somali Regional State, eastern Ethiopia: a cross-sectional study.

BMC Pediatr 2017 Aug 23;17(1):182. Epub 2017 Aug 23.

Epidemiology and Biostatistics Unit, Department of Public Health, College of Medicine and Health Sciences, Jigjiga University, Jigjiga, Somali Regional State, Ethiopia.

Background: The prevalence of underfive diarrhea in Somali Regional State, Ethiopia is one of the highest in the country. This study attempted to examine the multiple factors associated with underfive diarrhea and how they might influence its prevalence in Jigjiga, Somali regional state, Ethiopia.

Methods: A community based cross-sectional study was conducted from February 15 to 28, 2015. Read More

View Article
August 2017
19 Reads
1 PubMed Central Citation(source)
1.92 Impact Factor

Facile synthesis of phosphine free ultra-small PbSe nanocrystals and their light harvesting studies in ETA solar cells.

Dalton Trans 2014 Nov;43(43):16424-30

Department of Physics, Polymers & Materials Synthesis (PMS) Lab, COMSATS, Institute of Information Technology, Park Road, Islamabad 44000, Pakistan.

Ultra-small PbSe nanocrystals (NCs) were synthesized via a 'one-pot' approach in olive oil as the reaction medium and capping agent. The optical spectra showed discernible blue shifts in the absorption band edges (570-780 nm) due to strong quantum confinement effects and photoluminescence (PL) spectra showed significant strong emission peaks in the range of 780-850 nm. The broad peaks in the powder X-ray diffraction (p-XRD) pattern indicate the ultra-small size of the as-prepared NCs. Read More

View Article
November 2014
46 Reads
4.20 Impact Factor

Effect of reverse photoperiod on in vitro regeneration and piperine production in Piper nigrum L.

C R Biol 2014 Jan 16;337(1):19-28. Epub 2013 Dec 16.

Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, 25120 Peshawar, Pakistan. Electronic address:

In this study, a novel approach for in vitro regeneration of Piper nigrum L. has been applied in order to increase healthy biomass, phytochemicals and piperine production via reverse photoperiod (16hD/8hL). Leaf portions of the seed-derived plants were placed on an MS-medium fortified with different PGRs. Read More

View Article
January 2014
9 Reads
1 PubMed Central Citation(source)
0.98 Impact Factor