Epilepsia 2018 01 20;59(1):67-78. Epub 2017 Nov 20.
Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.
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Epilepsy Res 2014 May 5;108(4):675-83. Epub 2014 Mar 5.
Neuroscience TA, UCB Pharma, Braine-l'Alleud, Belgium. Electronic address:
Corneal kindling is a useful alternative to electrically induced amygdala or hippocampal kindling, which requires advanced surgical and EEG techniques that may not be easily available in many laboratories. Therefore the first aim of this study was to evaluate whether repeated 6 Hz corneal stimulation in mice would lead to an increased and persistent seizure response as described for higher frequency (50/60 Hz) corneal kindling. Male NMRI mice stimulated twice daily (except weekends) for 3 s with 6 Hz electrical current at 44 mA displayed robust kindling development, i. Read More
Epilepsy Res 1999 Nov;37(2):109-20
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany.
Electrical kindling via unilateral implanted depth electrodes in rats is currently the most commonly used model for temporal lobe epilepsy, but the use of this model in drug screening for the identification of novel anticonvulsants is markedly hampered by the laborious and time-consuming preparation and the size of the animals. Kindling of male mice via transcorneal electrical stimulation has recently proposed as a cost-effective screening model that may improve the preclinical evaluation of efficacy and adverse effect potential of drug candidates for treatment of partial epilepsy. In the present study, corneal kindling was characterized and compared in male and female mice. Read More
Neurobiol Dis 2017 Sep 15;105:221-234. Epub 2017 Jun 15.
Interdepartmental Neuroscience Program, University of Utah, Salt Lake City, UT 84108-1210, USA; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84108-1210, USA; Anticonvulsant Drug Development Program, University of Utah, Salt Lake City, UT 84108-1210, USA. Electronic address:
Memory deficits have a significant impact on the quality of life of patients with epilepsy and currently no effective treatments exist to mitigate this comorbidity. While these cognitive comorbidities can be associated with varying degrees of hippocampal cell death and hippocampal sclerosis, more subtle changes in hippocampal physiology independent of cell loss may underlie memory dysfunction in many epilepsy patients. Accordingly, animal models of epilepsy or epileptic processes exhibiting memory deficits in the absence of cell loss could facilitate novel therapy discovery. Read More
Neuroscience 2014 Apr 31;265:158-71. Epub 2014 Jan 31.
Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A5, Canada. Electronic address:
Amygdala kindling is well known to increase unconditioned fear and anxiety. However, relatively little is known about whether this form of kindling causes functional changes within the neural circuitry that mediates fear learning and the retrieval of fear memories. To address this issue, we examined the effect of short- (i. Read More