The HMGA1 Pseudogene 7 Induces miR-483 and miR-675 Upregulation by Activating Egr1 through a ceRNA Mechanism.

Genes (Basel) 2017 Nov 17;8(11). Epub 2017 Nov 17.

Istituto di Endocrinologia ed Oncologia Sperimentale del CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Scuola di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli "Federico II", via Pansini, 5, 80131 Naples, Italy.

Several studies have established that pseudogene mRNAs can work as competing endogenous RNAs and, when deregulated, play a key role in the onset of human neoplasias. Recently, we have isolated two pseudogenes, and . These pseudogenes have a critical role in cancer progression, acting as micro RNA (miRNA) sponges for and other cancer-related genes. pseudogenes were found overexpressed in several human carcinomas, and their expression levels positively correlate with an advanced cancer stage and a poor prognosis. In order to investigate the molecular alterations following pseudogene overexpression, we carried out miRNA sequencing analysis on overexpressing mouse embryonic fibroblasts. Intriguingly, the most upregulated miRNAs were miR-483 and miR-675 that have been described as key regulators in cancer progression. Here, we report that upregulates miR-483 and miR-675 through a competing endogenous RNA mechanism with , a transcriptional factor that positively regulates miR-483 and miR-675 expression.

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http://dx.doi.org/10.3390/genes8110330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704243PMC
November 2017
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