Endocrine disrupters and pubertal timing.

Curr Opin Endocrinol Diabetes Obes 2018 02;25(1):49-54

Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Purpose Of Review: The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing.

Recent Findings: In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty.

Summary: The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies.

Download full-text PDF

Source
http://dx.doi.org/10.1097/MED.0000000000000377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009831PMC
February 2018
8 Reads

Publication Analysis

Top Keywords

timing puberty
8
pubertal timing
8
lead delay
4
delay pubertysummary
4
organochlorine pesticides
4
compounds organochlorine
4
pubertysummary effects
4
pesticides lead
4
edcs pubertal
4
dimorphic compound
4
compound specific
4
sexually dimorphic
4
timing sexually
4
dioxin-like compounds
4
effects edcs
4
insecticides dioxin-like
4
puberty boys
4
boys prepubertal
4
puberty puberty
4
earlier timing
4

Similar Publications