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Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. | PubFacts

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure.

Authors:
Angela Lombardi
Angela Lombardi
Second University of Naples
Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy

Cell Commun Signal 2017 Nov 13;15(1):47. Epub 2017 Nov 13.

Department of Medicine, Albert Einstein College of Medicine, New York, NY, USA.

Background: One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not been fully clarified.

Methods: We studied the effects of the therapeutic dose of tacrolimus on mitochondrial fitness in beta-cells.

Results: We demonstrate that tacrolimus impairs glucose-stimulated insulin secretion (GSIS) in beta-cells through a previously unidentified mechanism. Indeed, tacrolimus causes a decrease in mitochondrial Ca uptake, accompanied by altered mitochondrial respiration and reduced ATP production, eventually leading to impaired GSIS.

Conclusion: Our observations individuate a new fundamental mechanism responsible for the augmented incidence of diabetes following tacrolimus treatment. Indeed, this drug alters Ca fluxes in mitochondria, thereby compromising metabolism-secretion coupling in beta-cells.

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Source
http://dx.doi.org/10.1186/s12964-017-0203-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684747PMC
November 2017
13 Reads
3 Citations
3.380 Impact Factor

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References

(Supplied by CrossRef)
Article in Clin Chem
PE Wallemacq et al.
Clin Chem 1993
Article in N Engl J Med
BJ Nankivell et al.
N Engl J Med 2003
Article in Nephrol Dial Transplant
R Chanchlani et al.
Nephrol Dial Transplant 2017
Article in Pediatr Transplant
MO Regelmann et al.
Pediatr Transplant 2015
Article in Ann Hepatol
AR Andrade et al.
Ann Hepatol 2017
Article in Expert Opin Drug Metab Toxicol
EB Rangel et al.
Expert Opin Drug Metab Toxicol 2014
Article in Transplant Proc
A Sessa et al.
Transplant Proc 2009
Article in Transplant Proc
M Weir et al.
Transplant Proc 2001
Article in Curr Diabetes Rev
N Montero et al.
Curr Diabetes Rev 2015
Article in Sci Rep
M Bhat et al.
Sci Rep 2017

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