General Two-Dimensional Absorption-Mode J-Resolved NMR Spectroscopy.

Anal Chem 2017 Dec 15;89(23):12646-12651. Epub 2017 Nov 15.

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University , Xiamen, Fujian 361005, China.

Two-dimensional (2D) J-resolved NMR technique offers a natural solution for disentangling complex mixtures that suffer from crowded spectra in 1D NMR. The applicability of classical 2D J-resolved spectroscopy is inevitably limited by phase-twist lineshapes and strong coupling artifacts. Here, a general and robust NMR method is proposed to record 2D absorption-mode J-resolved spectra in rapid acquisition manner. This method can also reduce the impact of strong coupling artifacts, thus achieving full considerations for applications. Intuitively, this method delivers pure chemical shifts along one dimension and orthogonally adds J couplings along the other dimension, free of 45° spectral shearing. It may provide a powerful tool for structural and configurational studies as well as biological analyses.

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http://dx.doi.org/10.1021/acs.analchem.7b02740DOI Listing
December 2017
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