Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome.

Authors:
Leeanne B Sherwin
Leeanne B Sherwin
National Institutes of Health
United States
Onyinyechi M Ozoji
Onyinyechi M Ozoji
National Institute of Nursing Research
Christina M Boulineaux
Christina M Boulineaux
National Institutes of Health
Dr. Paule V Joseph, PhD, RN, MS, FNP-BC, CTN-B
Dr. Paule V Joseph, PhD, RN, MS, FNP-BC, CTN-B
National Institute of Nursing Research
Tenure-Track Investigator (Clinical)
N/A
Bethesda , Maryland | United States
Nicolaas H Fourie
Nicolaas H Fourie
University of Cape Town
South Africa
Sarah K Abey
Sarah K Abey
National Institutes of Health
United States
Xuemin Zhang
Xuemin Zhang
College of Sciences
Orlando | United States

J Clin Med 2017 Nov 1;6(11). Epub 2017 Nov 1.

Digestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS ( = 41) and healthy volunteers ( = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL.

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Source
http://dx.doi.org/10.3390/jcm6110103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704120PMC
November 2017
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References

(Supplied by CrossRef)
Sex difference in irritable bowel syndrome: Do gonadal hormones play a role?
Mulak et al.
Gastroenterol. Pol. 2010

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