Diverse Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces cejpii F31-1.

Mar Drugs 2017 Nov 1;15(11). Epub 2017 Nov 1.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

By adding l-tryptophan and l-phenylalanine to GPY medium, twenty-eight compounds, including amides, polyketides, a sesquiterpenoid, a diterpenoid, a meroterpenoid, diketopiperazines, β-carbolines, fumiquinazolines, and indole alkaloids, were discovered from the marine-derived fungus F31-1, demonstrating the tremendous biosynthetic potential of this fungal strain. Among these compounds, four amides dichotomocejs A-D (-), one polyketide dichocetide A (), and two diketopiperazines dichocerazines A-B ( and ) are new. The structures of these new compounds were determined by interpreting detailed spectroscopic data as well as calculating optical rotation values and ECD spectra. Obviously, can effectively use an amino acid-directed strategy to enhance the production of nitrogen-containing compounds. Dichotomocej A () displayed moderate cytotoxicity against the human rhabdomyosarcoma cell line RD with an IC value of 39.1 µM, and pityriacitrin () showed moderate cytotoxicity against the human colon carcinoma cell line HCT116 with an IC value of 35.1 µM.

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http://dx.doi.org/10.3390/md15110339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706029PMC
November 2017
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