Am J Physiol Gastrointest Liver Physiol 2018 02 2;314(2):G287-G299. Epub 2017 Nov 2.
Department of Surgery, Brigham and Women's Hospital , Boston, Massachusetts.
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Am J Physiol Gastrointest Liver Physiol 2014 Sep 3;307(5):G588-93. Epub 2014 Jul 3.
Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts;
Studies suggest that improvements in type 2 diabetes (T2D) post- Roux-en-Y gastric bypass (RYGB) surgery are attributable to decreased intestinal glucose absorption capacity mediated by exclusion of sweet taste-sensing pathways in isolated proximal bowel. We probed these pathways in rat models that had undergone RYGB with catheter placement in the biliopancreatic (BP) limb to permit post-RYGB exposure of isolated bowel to sweet taste stimulants. Lean Sprague Dawley (n = 13) and obese Zucker diabetic fatty rats (n = 15) underwent RYGB with BP catheter placement. Read More
Medicine (Baltimore) 2017 Dec;96(48):e8859
Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira.
The objective is to access the role of Roux-en-Y gastric bypass (RYGB) biliopancreatic limb (BPL) length in type 2 diabetes (T2D) outcomes.RYGB is more effective than medical intervention for T2D treatment in obese patients. Despite the scarcity of available data, previous reports suggest that modifications of the RYGB limb lengths could improve the antidiabetic effects of the surgery. Read More
Dan Med J 2015 Apr;62(4):B5057
Department of Endocrinology, Hvidovre Hospital, Kettegårds Alle, 2650 Hvidovre. Denmark.
Roux-en-Y gastric bypass (RYGB) surgery induces weight loss of 20-30% that is maintained for 20 years. In patients with type 2 diabetes, the glucose-lowering effect of RYGB is superior to conventional antidiabetic therapy and often occurs within days after surgery. The aim of the thesis was to investigate the physiological mechanisms responsible for improved glycaemic control with special focus on the early postoperative period. Read More
Obes Surg 2018 Mar;28(3):599-605
Center for Bariatric and Metabolic Surgery, São Domingos Hospital, São Luís, Brazil.
Background: Type-2 diabetes (T2D) patients with body mass index (BMI) below 35 kg/m carry lower remission rates than severely obese T2D individuals submitted to "standard limb lengths" Roux-en-Y gastric bypass (RYGB). Mild-obese patients appear to have more severe forms of T2D, where the mechanisms of glycemic control after a standard-RYGB may be insufficient. The elongation of the biliopancreatic limb may lead to greater stimulation of the distal intestine, alterations in bile acids and intestinal microbiota, among other mechanisms, leading to better metabolic outcomes. Read More