Alteration in Electroencephalogram and Monoamine Concentrations in Rat Brain following Ibogaine Treatment.

Ann N Y Acad Sci 1998 May;844(1):265-273

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USADivision of R.O.W. Sciences, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA.

Ibogaine (IBO) is a psychoactive indole alkaloid that has antiaddictive properties. However, treatment with IBO may lead to neurotoxicity, since IBO and its metabolites interact persistently with many neurotransmitter systems. Here, we recorded cortical electroencephalogram (EEG) signals from rats anesthetized with isoflurane. The heart rate (HR) was monitored via electrocardiogram (EKG) electrodes. After the baseline EEG was recorded, rats received one intraperitoneal (i.p.) dose of 50 mg/kg IBO. EEG signals were recorded for 2 hr. Rats were then sacrificed and brains dissected into frontal cortex (FC), caudate nucleus (CN), hippocampus (HIP), and brain stem (BS). The level of dopamine (DA), serotonin (5-HT), and their metabolites were determined by high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Compared with baseline, a decrease in HR immediately after IBO injection and a decrease in δ, θ, α, and β power spectra frequency bands (1-4, 4-8, 8-13, 13-32Hz) during the first 30 min after IBO administration was observed. EEG recovered within the next 15 min. In CN, the level of DA decreased and DA turnover rate increased significantly. The levels of 5-HT increased in FC. The pattern of EKG and EEG response to IBO may be due to multiple receptor interactions of IBO.

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.1998.tb08241.xDOI Listing
May 1998
1 Read

Publication Analysis

Top Keywords

eeg signals
8
ibo
8
recorded rats
8
eeg
5
eeg recovered
4
sacrificed brains
4
rats sacrificed
4
recovered min
4
ibo eeg
4
signals recorded
4
brains dissected
4
observed eeg
4
cortex caudate
4
ibo administration
4
frontal cortex
4
administration observed
4
dissected frontal
4
mg/kg ibo
4
dose mg/kg
4
electrocardiogram ekg
4

Similar Publications