Endocan Concentration in Patients With Primary Hypertension.

Angiology 2018 Jul 30;69(6):483-489. Epub 2017 Oct 30.

1 Second Department of Nephrology and Hypertension with Dialysis Unit, Medical University of Bialystok, Bialystok, Poland.

Inflammation and endothelial dysfunction may play an important role in the multifactorial pathogenesis of hypertension. Endocan is also thought to play a role in cell adhesion and inflammatory disorders. The aim of the study was to compare endocan concentrations in patients with primary hypertension and healthy volunteers. There were 104 patients with hypertension (study group) and 21 healthy volunteers (control group). The correlation between endocan, catecholamines, and blood pressure control in patients with primary hypertension and the control group was analyzed. The median endocan concentration in the study group (2.03 ng/mL) was significantly higher than in the control group (1.09 ng/mL, P = .0001). Endocan concentration was correlated positively with renalase ( r = .2, P = .047) and norepinephrine ( r = .25, P = .02). Negative correlation was observed between endocan and body mass index ( r = -.25, P = .016) and leukocyte count ( r = -.36, P = .0004). The present study reports higher plasma endocan concentration in patients with treated, well-controlled primary hypertension compared with healthy volunteers. The higher endocan concentration in the study group may reflect endothelial dysfunction in this population.

Download full-text PDF

Source
http://dx.doi.org/10.1177/0003319717736158DOI Listing
July 2018
14 Reads

Publication Analysis

Top Keywords

endocan concentration
20
primary hypertension
16
patients primary
12
control group
12
study group
12
healthy volunteers
12
endocan
9
concentration study
8
endothelial dysfunction
8
play role
8
concentration patients
8
group
6
hypertension
6
patients
5
study
5
median endocan
4
analyzed median
4
plasma endocan
4
group 203
4
203 ng/ml
4

References

(Supplied by CrossRef)

Similar Publications