What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies.

Br J Haematol 2018 02 29;180(3):335-345. Epub 2017 Oct 29.

Laboratory of Haematology, La Timone Hospital, Marseille, France.

Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE-associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being claimed as VTE associated genes. Finally, several research strategies are briefly described to identify other molecular determinants of the disease.

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http://dx.doi.org/10.1111/bjh.15004DOI Listing
February 2018
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References

(Supplied by CrossRef)
Notch as a hub for signaling in angiogenesis
Benedito et al.
Experimental Cell Research 2013
The value of family history as a risk indicator for venous thrombosis
Bezemer et al.
Archives of Internal Medicine 2009

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